Denosyl for Dogs

A stable and pure salt of S-Adenosylmethionine, Denosyl is a veterinary supplement that helps boost hepatic function in dogs suffering from liver disease. As a supplement, Denosyl is highly effective in dealing with and managing liver issues in cats and dogs. Livers in mammals generate bile and other enzymes to promote digestion, synthesize proteins, and help remove toxins from the body.

Although the liver can eliminate toxins, an antioxidant named 'glutathione' further assists the organ in removing the toxins. However, damaged livers in dogs don't secrete sufficient 'glutathione' to ward off toxins that damage hepatic cells, necessitating Denosyl administration. The health of dogs suffering from liver disease keeps deteriorating, usually manifested by symptoms like seizures, ataxia, and hemolytic anemia.

Administering Denosyl to dogs with damaged liver keeps the above deficiencies at bay by boosting glutathione secretion, letting the liver function normally. The liver transforms S-Adenosylmethionine (SAMe) into glutathione and other derivates, thereby enhancing the bioavailability of the antioxidant. Denosyl increases the availability of SAMe, which in turn boosts the glutathione levels in the dog's liver.

This supplement also helps the dog's brain to produce more dopamine, melatonin, and serotonin, thus helping prevent depression and Alzheimer's.

 Denosyl at a Glance

Brand Name


Generic Name

SAMe (S-Adenosylmethionine)

Drug Type


Suitable for

Dogs and cats


Strictly through prescription

Available forms

Chewable tablets


When Should You Offer Denosyl to Your Dog?

The signs and symptoms of liver disease in dogs and cats are undetectable. Nevertheless, some specific symptoms and indications might enable your vet to decide whether your dog would require Denosyl. If you observe the following symptoms, then you can assume that your pet might be suffering from liver disease and must seek immediate medical intervention:-

  • Urinating and drinking water unusually
  • Recurrent vomiting and diarrhea
  • Reduced appetite
  • Abrupt weight loss

Failure to treat the condition will cause exacerbation whereby the liver swells up and undergoes cell attrition, eventually leading to jaundice, hepatic encephalopathy, cirrhosis, and several other conditions. These liver issues may vary in intensity; less severe conditions can be dealt with, while more acute forms are generally incurable.

Denosyl Pharmacokinetics in Dogs

Studies and research have demonstrated that the active ingredient in Denosyl (SAMe) works by enhancing glutathione levels in the liver. S-Adenosylmethionine has also been known to defend hepatic cells from attrition and eventual death and aid cell regeneration. Denosyl is most effective in supporting and improving the normal functioning of the liver in dogs and cats.

Nevertheless, advanced research has revealed that the supplement may also encourage cognitive functions in pets. Denosyl serves as a rich source of SAMe in a significantly stabilized and concentrated form, which helps improve canine liver and brain health.

How Much Denosyl Should You Administer to Your Pet?

You should always consult with your vet and discuss with the professional before offering Denosyl to your pet. The vet will prescribe an appropriate dosage based on your pet's weight and whether you have a large, medium, or small dog.


Dosage Table (for large, medium-sized, and small dog breeds)

Weight Range

Daily Dosage

Large dogs (35-65lb [16-29.5kg]); (66-120lb [30-54.5kg]); more than 120 lbs or 54.5 kg

1 x 425mg tablet; 2 x 425mg tablets; 425mg x 3 tablets respectively  

Medium-size dogs 13-34lbs (6-15.5kg)

1 x 225mg tablet

Small Dogs up to 12 lbs (5.5kgs)

1 x 90mg tablet


Denosyl available as chewable tablets works best when you offer the medication at least a couple of hours before nourishment. Do not divide or crush the tablet but instead provide the whole pill. You can give Denamarin in place of Denosyl (if it's not available) but talk with your vet first before proceeding.

Potential Side Effects and Drug Interactions

If you offer the prescribed dosage of Denosyl and follow the instructions on the labelling, then side effects may not occur. Additionally, Denosyl is also not known to interact with other veterinary medications.


Disclaimer: The above content is based on multiple research articles referred to online. Global Dog Breeds intends to share information, but it's strictly advised to consult a veterinarian and seek advice before using any medications described. We believe each condition and dog is unique, and only after careful evaluation from a qualified professional should you be offering any medications to your pet.

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