Deramaxx for Dogs

Deramaxx is an NSAID and a non-narcotic medication used for managing inflammation and pain related to osteoarthritis and postsurgical pain. Belonging to the Coxib class of anti-inflammatory, non-steroidal drugs, Deramaxx contains the active ingredient Deracoxib, helping control canine osteoarthritis for over 15 years. Available as chewable, beef-flavoured, chewable tablets, Deramaxx helps lessen OA (osteoarthritis) pain, fever, inflammation and postoperative pain.   

Deramaxx at a Glance

Brand Name


Generic Name


Drug Type

Oral NSAID (non-steroidal anti-inflammatory drug)

Does FDA approve the drug for pets?



 Exclusively for dogs


Through a veterinary prescription

Available Forms

Chewable tablets


Is Deramaxx Safe for Dogs?

FDA has approved veterinary Deramaxx exclusively for dogs, and one must follow the vet's instructions while administering the drug. Avoid offering the medication if your dog is allergic to the drug or any other NSAID. Additionally, steer clear of helping Deramaxx and other NSAIDs, including aspirin, Previcox, Metacam, and Rimadyl.

You can buy Deramaxx chewable tablets in 12mg, 25mg, 75mg, and 100mg doses. Ensure that you discuss your dog's medical history and ensure that they carry out a thorough physical examination. Keep in touch with your vet and let them know how your dog responds to treatment.

Action Mechanism of Deramaxx in Dogs

According to laboratory test data, Deramaxx interferes with the production of 6-Keto PGF1 and PGE1, inhibiting the action of prostaglandins biosynthesis. As a non-narcotic, non-steroidal Cyclooxygenase-inhibiting anti-inflammatory medication, Deramaxx obstructs COX-2 (Cyclooxygenase-2)-an enzyme that helps synthesize inflammatory agents. COX-1, as well as COX-2, is produced in the kidney of dogs.

Deramaxx starts acting on COX-2 in less than 24 hours of the dog taking the first dose of the medication.

How Much Deramaxx Should You Offer?

You must offer this medicine precisely in the manner suggested by your veterinarian. The exact dose of Deramaxx may vary based on the acuteness of the condition and the dog's weight, size, and age. Your vet will generally prescribe a dose of 0.45mg-0.91 mg/lb (1-2mg/kg) for postoperative- or osteoarthritic pain and inflammation.

The dose should be administered only once every 24-hours. For dogs suffering from inflammation and postoperative pain and weighing under or equivalent to 4lbs (1.8k), the recommended dosage is 1.4mg-1.8mg/lb (3-4mg/kg) per day. You can offer the medication without food or with food but make sure your pet drinks plenty of water.

Possible Side Effects of Deramaxx in Dogs

Deramaxx, like any other NSAID, can lead to side effects associated with the gastrointestinal tract, such as appetite loss, vomiting, and diarrhea. On the other hand, side effects regarded as more severe are not very common. Nevertheless, if you should watch for any of the following signs or symptoms, you should stop administering the medication and contact the vet:-

§ Skin changes (scabbing, inflammation, scratching)

§ Changes in urinary and drinking habits

§ Reduced appetite

§ Whitening of the eyes, yellowing of the skin and gums

§ Aggressive behavior

§ Incoordination

§ Decrease in activity level

Deramaxx Overdose Signs and Symptoms

  • Dark and tarry stool or bloody stool
  • Appetite loss
  • Diarrhea
  • Labored breathing
  • Seizures
  • Drowsiness
  • Lethargy

If you observe any of the above overdosing signs, get in touch with your vet as early as possible. Alternatively, you can contact the ASPCA's Animal Poison Control Center Helpline (1-888-426-4435).

Deramaxx Contraindications

Discontinue administering this NSAID if you find your dog hypersensitive to the drug or any other NSAID. Offering Deramaxx and other NSAIDs on a recurrent or long-term basis could cause abdominal or intestinal ulcers in your dog. Let your vet know if the pet:-

  • Is allergic to NSAIDs
  • Is hypertensive
  • Has congestive heart failure
  • Has heart disease
  • Has a bleeding disorder
  • Has peptic ulcer, kidney or liver disease
  • Is lactating or pregnant
  • Is taking Prednisone, Methylprednisolone, Prednisolone or any other steroid
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