Temaril-P for Dogs

Temaril-P also referred to as Temaril P is a drug that aids in the treatment of canine dermatitis, otitis, and eczema. Imbued with two active ingredients, Trimeprazine and Prednisolone, Temaril-P has anti-inflammatory and antipruritic qualities that help treat canine skin disorders. Usually recommended by vets to manage and get relief from allergic pruritis, Temaril-P makes the most of corticosteroids and antihistamines.

This judicious combination goes a long way in the effective treatment and management of atopic dermatitis and allergic otitis using a low dosage of corticosteroids. Tremaril-P comes in perfectly handy for effectively dealing with pruritis when other medications prove ineffective in managing itchy skin conditions.  This drug has also proven to be remarkably effective in coping with and getting relief from common cold conditions in dogs.

Hence veterinarians recommend Temaril-P not only for various skin disorders associated with dogs but also for the treatment of idiopathic cough, allergic bronchitis, and “kennel cough” (tracheobronchitis). 

 Temaril-P at a Glance

Generic Name

Trimeprazine with Prednisolone

Brand Name

Temaril-P®, Vanectyl-P®

Drug Type

An antihistamine with corticosteroid anti-inflammatory agent

Is the drug approved by FDA?


How to avail of the drug?

A vet’s prescription will be needed to buy the drug


Recommended for dogs

Available as (form)


Temaril-P: Is the Medication Safe for Dogs?

Though FDA has permitted the use of Temaril-P for canines, you should still consult a certified vet before administering the drug. According to a study conducted in 2010, it has been substantiated that Temaril-P can be safely used for monitoring and treating atopic dermatitis symptoms in dogs.

Temaril-P: Pharmacodynamics

Since Temaril-P is an antihistamine, the medication interferes with and blocks the neurotransmitter, histamine that is responsible for causing allergic reactions. The preventative and adjunctive action mechanism of Temaril-P helps in controlling and alleviating symptoms of coughing, itching, and inflammation.

Recommended Dosage

Make sure you discuss with your vet regarding the proper administration of Temaril-P to your pet. The following table displays the recommended dosages of Trimeprazine Tartrate and Prednisolone ingredients based on the body weight of the dog.


Weight of Dog

Trimeprazine Tartrate Daily Dosage (mg)

Prednisolone Daily Dosage (mg)

40lb +






11-20 lb



10 lb and/or less




Depending on how your dog responds to therapy initially (3-4 days), the vet may modify the dosage or keep it intact. As the treatment nears the end, the veterinarian gradually reduces the dosage to enable the dog to get rid of its dependency on the steroid. Ensure to give the tablets along with food for maximizing effectiveness, and if required you can easily break them into smaller parts

Possible Side Effects

Since Temaril P is a combination of an antihistamine (trimeprazine) and corticosteroid (prednisolone), it can cause a few side effects. Those likely to occur due to its trimeprazine content include:

The active ingredients in Temaril-P, namely prednisolone (corticosteroid) and trimeprazine (antihistamine) may cause some side effects. For instance, Trimeprazine an antihistamine could induce drowsiness, sleepiness, muscular weakness, trepidation, and depression. On the other hand, the side effects of corticosteroid Prednisolone include bloody diarrhea, vomiting, and slowly healing cuts and wounds.

Overdose Signs and Symptoms

  • Unwarranted drowsiness
  • Seizures
  • Low blood pressure

Offering Temaril-P on a long-term basis could also increase the risk of Cushing’s disease. Typical symptoms of Cushing’s disease include frequent urination, hunger, thirst, diarrhea and vomiting.

When You Should Not Offer Temaril-P?

If your dog is already taking medications like Quinidine, Phenobarbital, antidiarrheals, antacids and aspirin then Temaril-P may interact with these drugs. Therefore you must talk about the dog’s medical history and medicines you may be offering for any existing health issue. Exercise caution while administering this medication especially if your dog is:-

  • Pregnant (research has demonstrated that corticosteroids could activate labour prematurely along with other complications such as dystocia [painful delivery] and metritis [womb inflammation])
  • A diabetic (this’ll call for changing insulin dosage)
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